Motif ID: STAT5{A,B}.p2

Z-value: 1.163


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT5Ahg19_v1_chr17_+_40440481_404405690.553.8e-07Click!
STAT5Bhg19_v1_chr17_-_40428391_404284730.471.8e-05Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_44556163 29.381 NM_013361
 ZNF223
zinc finger protein 223
chr19_+_35168558 19.482 NM_001012320
NM_018443
 ZNF302

zinc finger protein 302

chr19_-_57988891 11.193 NM_001024596
NM_001144068
 ZNF772

zinc finger protein 772

chr4_-_76957139 9.416 NM_005409
 CXCL11
chemokine (C-X-C motif) ligand 11
chr19_+_44576266 9.203 NM_001037813
 ZNF284
zinc finger protein 284
chr19_+_44529493 7.434 NM_001129996
NM_013360
 ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr19_-_44405934 6.871 LOC100505715
uncharacterized LOC100505715
chr19_-_44952630 5.408 NM_014518
 ZNF229
zinc finger protein 229
chr19_-_58514136 5.226 ZNF606
zinc finger protein 606
chr1_+_220921576 5.191 NM_017898
 MARC2
mitochondrial amidoxime reducing component 2
chr19_-_37406918 4.858 NM_001171979
 ZNF829
zinc finger protein 829
chr19_+_37341724 4.202 NM_001242472
NM_001242474
 ZNF345

zinc finger protein 345

chr19_+_37407230 3.533 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
 ZNF568





zinc finger protein 568





chr9_+_70971814 3.378 NM_021965
 PGM5
phosphoglucomutase 5
chr5_+_178450775 3.175 NM_001136116
 ZNF879
zinc finger protein 879
chr4_+_84457256 2.742 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr10_-_98325100 2.626 TM9SF3
transmembrane 9 superfamily member 3
chr2_+_95831533 2.617 ZNF2
zinc finger protein 2
chr19_-_37341688 2.507 NM_001242800
 ZNF790
zinc finger protein 790
chr1_+_40997290 2.364 ZNF684
zinc finger protein 684
chr7_+_90032771 2.362 CLDN12
claudin 12
chr1_+_40942878 2.283 ZNF642
zinc finger protein 642
chr16_+_15596122 2.224 NM_001142469
 C16orf45
chromosome 16 open reading frame 45
chr19_+_37709068 2.163 ZNF383
zinc finger protein 383
chr5_+_178286913 2.148 NM_058230
 ZNF354B
zinc finger protein 354B
chr2_+_95831176 2.132 NM_001017396
NM_021088
 ZNF2

zinc finger protein 2

chr19_-_37341168 2.109 NM_001242801
 ZNF790
zinc finger protein 790
chr12_+_102271082 2.082 NM_018370
 DRAM1
DNA-damage regulated autophagy modulator 1
chr11_-_82996898 2.079 CCDC90B
coiled-coil domain containing 90B
chr19_+_58280996 2.071 NM_001077426
NM_001204814
NM_017652
 ZNF586


zinc finger protein 586


chr19_-_44905754 2.057 NM_152354
 ZNF285
ZFP112
zinc finger protein 285
zinc finger protein 112 homolog (mouse)
chr19_-_44860798 2.040 NM_001083335
NM_013380
 ZFP112

zinc finger protein 112 homolog (mouse)

chr19_+_58038692 2.036 NM_001199295
NM_153263
 ZNF549

zinc finger protein 549

chr19_-_37407079 1.981 NM_001037232
 ZNF829
zinc finger protein 829
chr19_-_36980336 1.907 NM_032838
NM_001145343
NM_001145344
NM_001145345
 ZNF566



zinc finger protein 566



chr7_+_90032647 1.891 NM_001185072
NM_001185073
NM_012129
 CLDN12


claudin 12


chr1_+_40997232 1.879 NM_152373
 ZNF684
zinc finger protein 684
chr7_-_93633527 1.827 NM_005868
 BET1
blocked early in transport 1 homolog (S. cerevisiae)
chr19_+_35225095 1.802 ZNF181
zinc finger protein 181
chr1_+_149871154 1.748 NM_016074
 BOLA1
bolA homolog 1 (E. coli)
chr3_+_58484091 1.731 NM_153331
 KCTD6
potassium channel tetramerisation domain containing 6
chr19_-_40596781 1.701 NM_001010880
NM_001142577
NM_001142578
NM_001142579
 ZNF780A



zinc finger protein 780A



chr12_-_10324675 1.675 NM_001172632
NM_001172633
NM_002543
 OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr3_+_14166543 1.644 TMEM43
transmembrane protein 43
chr19_+_37341259 1.624 NM_003419
 ZNF345
zinc finger protein 345
chr3_+_130745693 1.612 NM_001146003
NM_024800
NM_145910
 NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr16_-_53737713 1.579 NM_001127897
NM_015272
 RPGRIP1L

RPGRIP1-like

chr19_+_40502942 1.579 NM_178544
 ZNF546
zinc finger protein 546
chr19_-_37157718 1.560 NM_153257
 ZNF461
zinc finger protein 461
chr3_+_169940214 1.538 NM_002740
 PRKCI
protein kinase C, iota
chr7_-_108096693 1.513 NM_001193582
NM_001193583
NM_001193584
NM_005010
 NRCAM



neuronal cell adhesion molecule



chr19_-_37019169 1.508 NM_001012756
NM_001166036
NM_001166037
NM_001166038
 ZNF260



zinc finger protein 260



chr11_-_33722285 1.479 NM_001166692
 C11orf91
chromosome 11 open reading frame 91
chr19_+_35225124 1.479 ZNF181
zinc finger protein 181
chr3_-_157213138 1.470 NM_001167917
 VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr19_+_58258160 1.455 NM_173632
 ZNF776
zinc finger protein 776
chr3_+_14166632 1.455 TMEM43
transmembrane protein 43
chr3_+_14166582 1.443 TMEM43
transmembrane protein 43
chr19_+_58281049 1.419 ZNF586
zinc finger protein 586
chr3_-_183735617 1.409 NM_001023587
NM_005688
 ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr17_-_48945338 1.401 NM_001243877
 TOB1
transducer of ERBB2, 1
chr19_+_44331443 1.395 NM_181845
 ZNF283
zinc finger protein 283
chr11_-_82997376 1.389 NM_021825
 CCDC90B
coiled-coil domain containing 90B
chr3_+_14166439 1.345 NM_024334
 TMEM43
transmembrane protein 43
chr5_-_137514299 1.340 NM_001164326
NM_006696
NM_139199
 BRD8


bromodomain containing 8


chr20_-_25677173 1.303 NM_015655
 ZNF337
zinc finger protein 337
chr19_-_49250023 1.300 NM_182575
 IZUMO1
izumo sperm-egg fusion 1
chr19_+_58038744 1.300 ZNF549
zinc finger protein 549
chr19_+_58258189 1.299 ZNF776
zinc finger protein 776
chr19_+_35225479 1.298 NM_001029997
NM_001145665
 ZNF181

zinc finger protein 181

chr19_+_44716683 1.268 NM_182490
 ZNF227
zinc finger protein 227
chr8_-_110346272 1.250 NM_032869
 NUDCD1
NudC domain containing 1
chr14_-_20881577 1.227 NM_007110
 TEP1
telomerase-associated protein 1
chr20_-_18477811 1.208 NM_006606
 RBBP9
retinoblastoma binding protein 9
chr8_-_109260940 1.196 NM_001568
 EIF3E
eukaryotic translation initiation factor 3, subunit E
chr2_+_88991166 1.187 NM_144563
 RPIA
ribose 5-phosphate isomerase A
chr3_+_14166552 1.179 TMEM43
transmembrane protein 43
chr19_-_45004482 1.176 NM_013256
 ZNF180
zinc finger protein 180
chr19_+_44507076 1.155 NM_006300
 ZNF230
zinc finger protein 230
chr3_+_169940223 1.148 PRKCI
protein kinase C, iota
chr22_+_20748397 1.117 NM_003426
 ZNF74
zinc finger protein 74
chr19_+_57946662 1.106 NM_001023561
 ZNF749
zinc finger protein 749
chr19_-_58326280 1.104 NM_024762
 ZNF552
zinc finger protein 552
chr3_+_169940246 1.102 PRKCI
protein kinase C, iota
chr7_+_99102272 1.102 NM_145102
 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr6_-_27440459 1.101 NM_007149
 ZNF184
zinc finger protein 184
chr11_+_114167168 1.074 NNMT
nicotinamide N-methyltransferase
chr8_-_109260930 1.065 EIF3E
eukaryotic translation initiation factor 3, subunit E
chr1_-_3773760 1.060 NM_014704
 CEP104
centrosomal protein 104kDa
chr2_-_182521732 1.049 NM_001030311
NM_001030312
NM_001030313
NM_001160277
NM_201548
 CERKL




ceramide kinase-like




chr6_+_88182624 1.031 NM_001168398
NM_006416
 SLC35A1

solute carrier family 35 (CMP-sialic acid transporter), member A1

chr19_-_38085646 1.028 NM_016536
 ZNF571
zinc finger protein 571
chrX_-_154250769 0.976 NM_000132
 F8
coagulation factor VIII, procoagulant component
chr2_+_162164785 0.976 NM_005805
 PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr19_-_44809126 0.968 NM_004234
 ZNF235
zinc finger protein 235
chr1_-_212588235 0.960 TMEM206
transmembrane protein 206
chr4_-_89080010 0.954 NM_004827
 ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr11_+_73357222 0.944 NM_001130033
NM_021200
 PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr6_+_88182704 0.929 SLC35A1
solute carrier family 35 (CMP-sialic acid transporter), member A1
chr14_+_24630421 0.902 NM_006084
 IRF9
interferon regulatory factor 9
chr7_-_112758604 0.886 LOC401397
uncharacterized LOC401397
chr16_-_3085541 0.882 NM_001103175
 CCDC64B
coiled-coil domain containing 64B
chr8_+_8559665 0.880 NM_194284
 CLDN23
claudin 23
chr12_+_133657439 0.869 ZNF140
zinc finger protein 140
chr1_-_3773620 0.865 CEP104
centrosomal protein 104kDa
chr13_-_52378230 0.831 NM_001031719
NM_024705
 DHRS12

dehydrogenase/reductase (SDR family) member 12

chr7_-_95225802 0.829 NM_002612
 PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr1_-_212588239 0.796 NM_001198862
NM_018252
 TMEM206

transmembrane protein 206

chr15_+_90895476 0.781 NM_001004309
 ZNF774
zinc finger protein 774
chr10_+_44101854 0.779 NM_145312
 ZNF485
zinc finger protein 485
chr9_+_130186652 0.774 NM_007135
 ZNF79
zinc finger protein 79
chr9_+_15422862 0.768 SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr1_-_54519050 0.763 NM_004872
 TMEM59
transmembrane protein 59
chr20_+_58251715 0.762 NM_001199506
 PHACTR3
phosphatase and actin regulator 3
chr5_-_145562214 0.751 LARS
leucyl-tRNA synthetase
chr15_-_83735998 0.746 BTBD1
BTB (POZ) domain containing 1
chr17_+_15603046 0.744 ZNF286A
zinc finger protein 286A
chr8_-_146012653 0.743 NM_030580
 ZNF34
zinc finger protein 34
chr6_+_99968851 0.741 NM_001195131
 LOC100130890
uncharacterized LOC100130890
chr19_+_44455379 0.740 NM_013359
 ZNF221
zinc finger protein 221
chr19_-_36980758 0.735 ZNF566
zinc finger protein 566
chr3_+_122399665 0.734 NM_017554
 PARP14
poly (ADP-ribose) polymerase family, member 14
chr19_+_44764032 0.718 NM_001207005
NM_181756
 ZNF233

zinc finger protein 233

chr6_+_84569394 0.714 CYB5R4
cytochrome b5 reductase 4
chr10_-_121355978 0.702 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr6_-_83903632 0.694 NM_001199917
 PGM3
phosphoglucomutase 3
chr9_+_15422875 0.691 SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr6_+_84569364 0.682 NM_016230
 CYB5R4
cytochrome b5 reductase 4
chr1_-_54518915 0.673 TMEM59
transmembrane protein 59
chr6_-_45345574 0.673 NM_003599
NM_181356
 SUPT3H

suppressor of Ty 3 homolog (S. cerevisiae)

chr15_-_83736105 0.669 NM_001011885
NM_025238
 BTBD1

BTB (POZ) domain containing 1

chr5_-_145562068 0.666 LARS
leucyl-tRNA synthetase
chr2_+_44001177 0.663 NM_001193464
NM_015522
NM_016008
 DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr3_+_197677049 0.661 NM_000996
 RPL35A
ribosomal protein L35a
chr14_+_68286495 0.646 NM_002877
NM_133509
NM_133510
 RAD51B


RAD51 homolog B (S. cerevisiae)


chr6_+_84569427 0.640 CYB5R4
cytochrome b5 reductase 4
chr5_-_92916924 0.639 FLJ42709
uncharacterized LOC441094
chr4_+_130017281 0.638 NM_001099783
 C4orf33
chromosome 4 open reading frame 33
chr9_+_112542496 0.632 NM_053016
NM_007203
NM_147150
 PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr1_-_184724021 0.629 NM_025191
 EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr3_+_196466724 0.626 NM_002577
 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr17_-_17494906 0.622 NM_148172
 PEMT
phosphatidylethanolamine N-methyltransferase
chr10_+_44101883 0.619 ZNF485
zinc finger protein 485
chrX_+_105412297 0.617 NM_001171020
NM_152423
 MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr1_-_19217384 0.605 NM_001161504
 ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr7_-_112758611 0.602 LOC401397
uncharacterized LOC401397
chr19_-_37663567 0.600 NM_152655
 ZNF585A
zinc finger protein 585A
chrX_+_48334400 0.593 NM_012280
NM_177439
 FTSJ1

FtsJ homolog 1 (E. coli)

chr19_-_37958338 0.588 NM_152484
 ZNF569
zinc finger protein 569
chr22_-_38714088 0.584 NM_001894
 CSNK1E
casein kinase 1, epsilon
chr5_-_102898450 0.579 NM_031438
 NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr1_-_54518790 0.566 TMEM59
transmembrane protein 59
chr7_+_99102572 0.564 NM_014569
 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr9_+_15422630 0.564 NM_001039697
 SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr17_+_5323471 0.560 RPAIN
RPA interacting protein
chr1_-_155112720 0.552 NM_018973
NM_153741
 DPM3

dolichyl-phosphate mannosyltransferase polypeptide 3

chr6_+_139094656 0.536 NM_015439
 CCDC28A
coiled-coil domain containing 28A
chr8_-_144699621 0.533 TSTA3
tissue specific transplantation antigen P35B
chr3_+_66119284 0.531 NM_173471
 SLC25A26
solute carrier family 25, member 26
chr15_-_83735892 0.531 BTBD1
BTB (POZ) domain containing 1
chr11_-_134123138 0.528 NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298
 THYN1




thymocyte nuclear protein 1




chrX_+_134478671 0.525 NM_152695
 ZNF449
zinc finger protein 449
chr14_-_82000198 0.518 NM_001244984
NM_005065
 SEL1L

sel-1 suppressor of lin-12-like (C. elegans)

chr3_+_196466806 0.510 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr6_+_52226866 0.505 NM_133367
 PAQR8
progestin and adipoQ receptor family member VIII
chr8_+_110346549 0.497 NM_001193557
NM_020189
 ENY2

enhancer of yellow 2 homolog (Drosophila)

chr8_-_18666295 0.497 NM_206909
 PSD3
pleckstrin and Sec7 domain containing 3
chr22_-_38902315 0.494 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr12_+_133657478 0.490 ZNF140
zinc finger protein 140
chr12_-_15865847 0.489 EPS8
epidermal growth factor receptor pathway substrate 8
chr11_-_61124223 0.480 NM_001161452
 CYBASC3
cytochrome b, ascorbate dependent 3
chr17_+_61271354 0.478 TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr5_+_34687663 0.474 NM_001145523
 RAI14
retinoic acid induced 14
chr19_+_34895268 0.472 NM_032346
 PDCD2L
programmed cell death 2-like
chr2_-_63815761 0.469 NM_015910
 WDPCP
WD repeat containing planar cell polarity effector
chr16_+_53468344 0.466 NM_005611
 RBL2
retinoblastoma-like 2 (p130)
chr2_-_44223112 0.459 LRPPRC
leucine-rich PPR-motif containing
chr2_-_231084600 0.458 NM_004509
NM_004510
NM_080424
 SP110


SP110 nuclear body protein


chr2_+_172290796 0.436 DCAF17
DDB1 and CUL4 associated factor 17
chr16_+_53468390 0.431 RBL2
retinoblastoma-like 2 (p130)
chr5_-_145562235 0.422 NM_020117
 LARS
leucyl-tRNA synthetase
chr14_-_82000112 0.421 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr7_+_26400503 0.420 NM_001199837
 SNX10
sorting nexin 10
chr1_-_54518886 0.419 TMEM59
transmembrane protein 59
chr18_+_56807115 0.419 NM_033280
 SEC11C
SEC11 homolog C (S. cerevisiae)
chr1_-_33502464 0.415 AK2
adenylate kinase 2
chr4_+_2883636 0.415 ADD1
adducin 1 (alpha)
chr14_+_23235730 0.414 NM_005015
 OXA1L
oxidase (cytochrome c) assembly 1-like
chr6_+_88182679 0.413 SLC35A1
solute carrier family 35 (CMP-sialic acid transporter), member A1
chr7_+_99102601 0.413 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr9_+_132816186 0.407 GPR107
G protein-coupled receptor 107
chr11_-_9025531 0.394 NM_020645
 NRIP3
nuclear receptor interacting protein 3
chr16_+_53468362 0.392 RBL2
retinoblastoma-like 2 (p130)
chr12_+_16500075 0.391 NM_145792
 MGST1
microsomal glutathione S-transferase 1
chr18_+_43684297 0.389 NM_138443
 HAUS1
HAUS augmin-like complex, subunit 1
chr8_-_101965601 0.388 NM_003406
 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr12_-_12291374 0.385 LRP6
low density lipoprotein receptor-related protein 6
chr11_-_125773086 0.385 NM_031307
 PUS3
pseudouridylate synthase 3
chr12_-_49449106 0.383 NM_003482
 MLL2
myeloid/lymphoid or mixed-lineage leukemia 2
chr5_-_37184945 0.382 C5orf42
chromosome 5 open reading frame 42

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.99 2.56e-17 GO:0006355 regulation of transcription, DNA-dependent
4.62 9.45e-17 GO:2000112 regulation of cellular macromolecule biosynthetic process
4.80 9.67e-17 GO:0051252 regulation of RNA metabolic process
4.50 2.42e-16 GO:0010556 regulation of macromolecule biosynthetic process
4.37 6.90e-16 GO:0010468 regulation of gene expression
4.18 3.19e-15 GO:0031326 regulation of cellular biosynthetic process
4.13 4.73e-15 GO:0009889 regulation of biosynthetic process
4.07 2.83e-14 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.95 7.81e-14 GO:0051171 regulation of nitrogen compound metabolic process
3.41 1.17e-12 GO:0060255 regulation of macromolecule metabolic process
3.24 7.24e-12 GO:0080090 regulation of primary metabolic process
3.20 1.16e-11 GO:0031323 regulation of cellular metabolic process
2.90 3.21e-10 GO:0019222 regulation of metabolic process
1.96 5.51e-07 GO:0050794 regulation of cellular process
1.81 3.16e-06 GO:0065007 biological regulation
1.85 4.99e-06 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.24 1.14e-08 GO:0005634 nucleus
1.62 1.89e-05 GO:0043231 intracellular membrane-bounded organelle
1.62 1.98e-05 GO:0043227 membrane-bounded organelle
1.49 3.36e-04 GO:0043229 intracellular organelle
1.48 3.59e-04 GO:0043226 organelle
1.34 5.19e-03 GO:0044424 intracellular part
1.30 1.43e-02 GO:0005622 intracellular
1.14 4.65e-02 GO:0044464 cell part
1.14 4.67e-02 GO:0005623 cell

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
5.22 2.82e-19 GO:0008270 zinc ion binding
4.59 2.87e-17 GO:0046914 transition metal ion binding
4.48 2.66e-16 GO:0003677 DNA binding
3.24 5.32e-12 GO:0003676 nucleic acid binding
2.87 4.34e-11 GO:0046872 metal ion binding
2.84 6.38e-11 GO:0043169 cation binding
2.83 6.94e-11 GO:0043167 ion binding